Amyloid Planet: Perspectives on Amyloidosis and Protein Misfolding Disorders | oneAMYLOIDOSISvoice

Amyloid Planet: Perspectives on Amyloidosis and Protein Misfolding Disorders


The most widely used system is the European modification of the original 3-stage Mayo 2004 system which uses Troponin T or I and NT-pro-BNP to divide patients into Stages 1, 2, 3a and 3b. The Mayo 2012 system, which incorporates serum free light chain levels, is another 4-stage variation on this theme. 

Finally, there is a British cardiac staging system for transthyretin (ATTR) amyloidosis which was the subject of a prior amyloidosis JC discussion. What all of these publications have in common is the use of NT-pro-BNP as a key cardiac biomarker. What all medical centers don’t have in common is the ability to order this test without having to send out a blood sample.  

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