Merrill Benson, MD | oneAMYLOIDOSISvoice
Researchers

Merrill Benson, MD

Researcher
Professor
Department of Pathology
and Laboratory Medicine
Indiana University School of Medicine
635 Barnhill Drive, MS-A128
Indianapolis, Indiana, United States

Merrill Benson is a Professor of Pathology & Laboratory Medicine at Indiana University School of Medicine. He completed B.A in 1961, M.S. Pathology in 1964 and M.D in 1965 from the University of Vermont. He completed Residency in Internal Medicine from Bellevue Hospital and Boston City Hospital and Fellowship in Rheumatology from Boston University School of Medicine. He joined the faculty of Indiana University in 1976 as Associate Professor of Medicine and became Professor of Medicine in 1981 and Professor of Medical Genetics in 1984.

Professor Benson is an internationally recognized expert in the field of amyloidosis. He has discovered the origin of several forms of hereditary amyloidosis, including those related to mutations in apolipoprotein-A1 and Fibrinogen Aa -chain. His research has revealed structural changes of proteins which are related to the transition of proteins and the beta stucture that is characterstic of amyloid fibrils. These studies have included basic research on proteins implicated in amyloidosis of human immunoglobulin (AL), reactive (SAA) and hereditary (TTR) forms of amyloidosis. His research has also led to significant discoveries in the area of Alzheimer disease, a form of amyloidosis localized to the central nervous system.

 

Representative Publications:

A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils

A transthyretin variant (alanine 71) associated with familial amyloidotic polyneuropaidosis (ISA) nomenclature committee

Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee

Inotersen (transthyretin-specific antisense oligonucleotide) for treatment of transthyretin amyloidosis

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