Trusted Resources: Education
Scientific literature and patient education texts
Cardiac Amyloidosis: Pathology, Nomenclature, and Typing
source: Cardiovascular Pathology: The Official Journal of The Society for Cardiovascular Pathology
year: 2015
authors: Maleszewski JJ
summary/abstract:Amyloidosis is an increasingly recognized cause of heart disease, caused by the deposition of misfolded protein within the heart. These proteins may deposit systemically and include the heart or deposit only within the heart muscle itself. In either case, cardiac symptoms may be the primary manifestation. The diagnosis is usually made by the pathologist identifying amyloid within a tissue sample. The diagnosis, however, does not end with such visual recognition of the presence of amyloid.
Newer generation pharmacotherapeutic agents that are protein specific necessitate a closer evaluation to determine the type of protein being deposited and accurately conveying this to the treating clinician. Herein, the gross and histopathologic features of cardiac amyloidosis are reviewed along with a review of amyloid typing strategies (both direct and indirect) that may be employed in the diagnostic workup as well as the nomenclature standards for reporting.
organization: Mayo Clinic, USADOI: 10.1016/j.carpath.2015.07.008
read more
Related Content
-
Left Ventricular Myocardial Deformation on Cine MR Images: Relationship to Severity of Disease and Prognosis in Ligh...Purpose: To measure left ventricular (L...
-
Recent Advances in the Noninvasive Strategies of Cardiac AmyloidosisThe heart, like any organ in the body, i...
-
Acoramidis Reduces All-Cause, Cardiovascular Mortality at 30 Months in ATTR-CMThe 30-month results of the phase 3 ATTR...
-
Cardiac Amyloidosis – the Great Imitatorhttps://www.youtube.com/watch?v=7DQotydY...
-
Association of Black CardiologistsFounded in 1974, the Association of Blac...
-
Genetic Counseling for Hereditary TTR Amyloidhttps://www.youtube.com/watch?v=w97DLzdt...
-
Normal Scores of Deep Breathing Tests: Beware of Dysrhythmia in Transthyretin AmyloidosisBackground: The heart rate (HR) respons...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.