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Hepatic Amyloidosis: A Cause of Rapidly Progressive Jaundice

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source: BMJ Case Reports

year: 2018

authors: Ford M, Disney B, Shinde V, Ishaq S

summary/abstract:

An 83-year-old man presented with an acute history of weight loss and jaundice. He had a history of type 2 diabetes mellitus and hypertension. He consumed 30 units of alcohol per week. The patient was cachectic and jaundiced with non-tender hepatomegaly and no evidence of chronic liver disease. There was evidence of hypoalbuminaemia (albumin 25 g/L, reference 34–51 g/L), hyperbilirubinaemia (bilirubin 188 μmol/L, reference <22 μmol/L) and a raised alkaline phosphatase (629 IU/L, reference 35–105 IU/L). 
 
Full blood count, coagulation tests and the remaining liver function tests were normal. An estimated Glomerular filtration rate (eGFR) was 71 mL/min/1.73 m2. Autoantibodies and immunoglobulins were normal. Hepatitis viral serology was negative. Serum light chain measurements revealed kappa chain concentration of 13.3 (reference 3.3–19.4 mg/L) and lambda chain concentration of 28.5 (reference 5.7–26.6 mg/L) with a ratio of 0.47 (reference 0.26–1.75).
 
organization: Queen Elizabeth Hospital Birmingham, UK; University Hospitals Coventry and Warwickshire NHS Trust, UK; Dudley Group of Hospital, UK

DOI: 10.1136/bcr-2017-222942

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