Case Report: Treatment of Light-Chain Amyloidosis With Daratumumab Monotherapy in Two Patients | oneAMYLOIDOSISvoice
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Case Report: Treatment of Light-Chain Amyloidosis With Daratumumab Monotherapy in Two Patients

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source: European Journal of Haematology

year: 2018

authors: Gran C, Gahrton G, Alici E, Nahi H

summary/abstract:

Immunoglobulin light-chain amyloidosis (AL) affects multiple organs, most prominently the kidney and the heart. Renal and cardiac impairment are both associated with poor prognosis and most patients die as a consequence of renal or cardiac failure. Monoclonal antibodies such as daratumumab (human IgG1 anti-CD38) and elotuzumab (anti-SLAMF7) have shown promising efficacy for the treatment of relapsed and refractory multiple myeloma. 
 
In this case report we show 2 patients with severe AL, one with severe heart failure and one with heart and renal failure, undergoing treatment with daratumumab. Both patients showed a rapid decrease in FLC in response to daratumumab infusions, with few associated adverse events. Using therapeutic CD38 antibodies as a front-line treatment for AL could induce rapid responses while maintaining a tolerable safety profile in these ultra-fragile patients.
 
organization: Karolinska Institutet Department of Medicine Huddinge, Sweden

DOI: 10.1111/ejh.13008

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