Mistaken Identity: Using Bone Scintigraphy to Diagnose Cardiac Amyloidosis in Patients With a Monoclonal Gammopathy | oneAMYLOIDOSISvoice
×
Or register here
Global Search

Trusted Resources: Education

Scientific literature and patient education texts

Back to Education / Scientific Articles

Mistaken Identity: Using Bone Scintigraphy to Diagnose Cardiac Amyloidosis in Patients With a Monoclonal Gammopathy

key information

source: JACC: CardioOncology

year: 2021

authors: Andrew T. Nguyen, Kevin M. Alexander

summary/abstract:

Cardiac amyloidosis (CA) occurs when amyloid fibrils infiltrate the myocardial interstitium, resulting in stiffened myocardium and a restrictive cardiomyopathy. More than 95% of CA is due to systemic light chain amyloidosis (AL) or transthyretin amyloidosis (ATTR). AL amyloidosis arises from a clonal plasma cell dyscrasia that produces amyloidogenic monoclonal immunoglobulins.
 
These immunoglobulins then misfold and deposit in various organs, such as the heart, kidneys, liver, gastrointestinal tract, and peripheral nerves. ATTR amyloidosis arises when transthyretin, a liver-derived transporter of thyroid hormone and retinol proteins, undergoes tetramer dissociation, misfolds, and forms amyloid fibrils in various distant organs.
 
organization: Stanford University School of Medicine, USA

DOI: 10.1016/j.jaccao.2021.06.002

read more

Related Content

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close

Community Key Collaborator

Support for this landing page is provided by an independent education grant from

Translation of this platform made possible through an independent education grant from

© 2024 rareLife solutions Inc.

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close